The acknowledged effect of these PTMs on ATXN2’s functionality and SCA2 pathogenesis stays constrained. In other polyQ diseases, numerous scientific studies proposed that proteolytic cleavage of polyQ proteins could Perform a vital part in pathogenesis [36, forty five]. Aligned using this thought, the presence of the enriched 42 kDa fragment in https://cpth254321.develop-blog.com/34431315/fascination-about-isa-2011b