Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals within the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have recognized recurrent mutations in genes regulating tumor mobile-microenvironment inter... https://yasunaris631ksb8.luwebs.com/profile