[114] Activation of the ECS system in MS (and EAE) appears to limit neuronal hurt by downregulation of cannabinoid receptors inhibiting GABA synapses as a protecting motion to reduce neuronal excitotoxic harm. Upregulation of endocannabinoid tone protects neurons from excitotoxicity in parallel with a therapeutic result in the mouse model https://zionlwhwe.collectblogs.com/77937388/medical-marijuana-things-to-know-before-you-buy