Pentobarbital will lessen the level or result of saxagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown. pentobarbital will decrease the extent or impact of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib can be a sensitive CYP3A4 substrate. Coadministration with strong or average CYP3A4 induc... https://janez048nyg7.webdesign96.com/profile